Fat, BMI growth may lead to high blood vessel diseases risk, according to the research disclosed in European Heart Journal. A group of analysts, driven by associate professor and senior scientist, Susanna Larsson from the Karolinska Institute, Stockholm, Sweden, examined 96 genetic variations related with BMI and body fat mass to gauge their impact on 14 cardiovascular diseases in 367,703 members of white-British plunge in UK Biobank, a UK-based national and worldwide asset containing data on 500,000 individuals, aging 40-69 years.
Larsson said, “The causal association between BMI and fat mass and several heart and blood vessel diseases, in particular aortic valve stenosis, was unknown. Using Mendelian randomisation we found that higher BMI and fat mass are associated with an increased risk of aortic valve stenosis and most other cardiovascular diseases, suggesting that excess body fat is a cause of cardiovascular disease.”
In the findings of the research, the analysts additionally discovered that the risk of cardiovascular diseases expanded with the genetic variations foreseeing increments in fat mass. The best expanded hazard was additionally for aortic valve stenosis (46% expanded hazard), trailed by transient ischaemic attack, ischaemic stroke, heart failure, atrial fibrillation, deep vein thrombosis, peripheral artery disease, coronary artery disease, and high blood pressure.
“Our genes can make us somewhat more predisposed to gain body weight but lifestyle factors, such as overeating and lack of physical activity, are the major determinants of overweight,” Larsson added. “A healthy diet is the cornerstone of cardiovascular disease prevention, and how much we eat should be limited to the amount of energy required to maintain a healthy body weight, which is a BMI of between 20 to 25 kg/m2.”